Deterministic Integrity Gates for LLM-Assisted Clinical Manuscript Preparation: An Auditable Biomedical Informatics Architecture

The article presents the MedSci Skills toolkit, an open-source architecture designed for LLM-assisted clinical manuscript preparation, emphasizing a verification framework that integrates deterministic integrity checks. This toolkit comprises 43 skills, including a 21-detector deterministic tier, which successfully identified all 27 injected defects in tested pipelines (STARD, PRISMA, STROBE) without false positives, outperforming a single-prompt LLM reviewer. This approach enhances the reliability of LLM outputs by providing an auditable and reproducible verification process, crucial for practitioners aiming to ensure the integrity of AI-generated scientific manuscripts.