SP-Mind: An Autonomous Reasoning Agent for Spatial Proteomics Analysis

SP-Mind is introduced as the first autonomous AI agent specifically designed for spatial proteomics analysis, streamlining the process from raw multiplexed tissue imaging to phenotype discovery without requiring task-specific fine-tuning. It utilizes expert-curated biological analysis skills and specialized computational tools, and its performance is rigorously evaluated using SP-Bench, a benchmark consisting of 102 tasks across 18 categories, where SP-Mind demonstrates state-of-the-art results compared to existing biomedical agent baselines. This development is significant for practitioners as it enhances scalability and reproducibility in spatial proteomics research, facilitating more efficient analysis workflows in precision medicine.